ncRNA name | hsa-miR-17 |
ncRNA Category | miRNA |
Disease name | retinoblastoma (RB) |
Species | Homo sapiens |
Tissues/Cell_line | retinas; RB cell lines RBL15, WERI-RB1 and Y79 |
Methods | qPCR, transfection, immunoblot |
Expression pattern | up-regulated |
Functional description | miR-17-92 inactivation suppresses retinoblastoma formation in mice and co-silencing of miR-17/20a and p53 cooperatively decreases the viability of human retinoblastoma cells. |
PubMed ID | 22864477 |
Year | 2012 |
Title | Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation. |
Drug-related ncRNA | NO |
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